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. Author manuscript; available in PMC: 2010 Aug 25.
Published in final edited form as: Brain Res. 2009 Jun 25;1286:75–83. doi: 10.1016/j.brainres.2009.06.058

Figure 4.

Figure 4

Picrotoxin (PTX) attenuated propofol-induced changes in both phasic and tonic GABAA currents in a concentration-dependent fashion. In a single representative neuron, 10 µM propofol induced both a tonic inward current and prolonged sIPSCs in Control (compare upper two original traces). Note that sIPSCs were typically quite brief and infrequent in Control. Propofol evoked changes were attenuated by 10 or 20 µM PTX and sIPSCs became less frequent. Traces show both pre- and postsynaptic actions of propofol within a single representative neuron (VH = −60 mV). On average (lower graph), PTX inhibited propofol induced tonic currents to near baseline levels at or above 10 µM (n= 4 to 8 different neurons). Points indicate mean and SEM.