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Specificity control of the effect of PACAP on caspase-3 activity. (A) Effect of PACAP (10−8 M) in the absence or presence of the PACAP antagonist PACAP(6–38) (10−6 M) on caspase-3 activity. (B) Effect of PACAP (10−7 M) in the absence or presence of the specific caspase-3 inhibitor (Ac-DEVD-CHO) (5 × 10−7 M) on caspase-3 activity. **, P < 0.01; ***, P < 0.001; NS, not statistically different.
