Table 2.
Association of risk allele scores with type 2 diabetes
| Alleles | Count (frequency) | Age at diagnosisa (years, mean ± SD) | OR for T2D (95% CI) | p value OR for T2D | |
|---|---|---|---|---|---|
| Controls (n = 2,041) | Cases (n = 2,628) | ||||
| 0 or 1 | 76 (4.2) | 115 (4.9) | 57.5 ± 1.1 | 0.75 (0.55–1.02) | 0.07 |
| 2 | 243 (13.5) | 352 (15.0) | 57.3 ± 0.6 | 0.78 (0.64–0.95) | 0.02 |
| 3 | 522 (29.0) | 667 (28.4) | 56.1 ± 0.5 | 0.89 (0.76–1.04) | 0.14 |
| 4 | 605 (33.6) | 685 (29.1) | 55.6 ± 0.4 | 1.00 | ref |
| 5 | 288 (16.0) | 381 (16.2) | 56.1 ± 0.6 | 1.17 (0.97–1.41) | 0.11 |
| 6–8 | 65 (3.6) | 151 (6.4) | 52.9 ± 0.9 | 2.05 (1.50–2.80) | 4 × 10−6 |
aAge at diagnosis was available for 2,132 participants with type 2 diabetes
βage at diagnosis = −0.46 (−0.80 to −0.11) years, p = 0.009 adjusted for sex
The OR for type 2 diabetes and p value were compared with the four risk alleles group as a reference (ref)
The OR for type 2 diabetes for less than three vs four risk alleles was 0.77 (0.65–0.93), p = 0.005 and the OR for type 2 diabetes for more than four vs four risk alleles was 1.33 (1.12–1.58), p = 0.001
T2D, type 2 diabetes