Table 2.
Dose response IC50 values of AOP fractions following peroxidase-catalyzed oxidation of apocynin and silica gel chromatography.
| Fraction | Log (IC50) (IC50 in parentheses, μM) Cell-based assay | Log (IC50) (IC50 in parentheses, μM) ELISA assay |
|---|---|---|
| Apocynin | 3.04 ± 0.49 (1090) | 4.78 ± 6.65 (61,000) |
| IIIHyQ | −1.51 ± 0.05 (0.03) | 0.20 ± 0.15 (1.60) |
| AOP-2 | −1.40 ± 0.05 (0.04) | −0.27 ± 0.15 (0.55) |
| AOP-3 | −0.61 ± 0.08 (0.25) | 1.70 ± 0.15 (50.0) |
| AOP-4 | −0.67 ± 0.10 (0.22) | 0.47 ± 0.18 (2.96) |
| AOP-5 | 0.34 ± 0.11 (2.20) | 0.44 ± 0.90 (7.96) |
| AOP-6 | −0.09 ± 0.09 (0.82) | 2.01 ± 0.16 (103) |
| AOP-7 | 0.001 ± 0.06 (1.00) | 2.66 ± 456 (453) |
| AOP-8 | 0.03 ± 0.22 (1.08) | 2.38 ± 0.08 (239) |
| AOP-9 | −0.04 ± 0.13 (0.92) | 1.54 ± 0.08 (34.8) |
| AOP-10 | −0.11 ± 0.12 (0.78) | 2.03 ± 0.08 (107) |