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. Author manuscript; available in PMC: 2009 Aug 10.
Published in final edited form as: Cell Cycle. 2008 Dec 22;7(23):3775–3780. doi: 10.4161/cc.7.23.7240

Figure 3. E2f3−/− mice develop congestive heart failure.

Figure 3

(A) Whole mount pictures of hearts from E2f3−/− mice and a wildtype littermate which were sacrificed at 15 months of age. (B) Cardiac dilation of E2f3−/− animals measured by left ventricular cavity diameter/left ventricular wall thickness from histology sections. Red diamonds indicate mice that died from congestive heart failure and blue diamonds indicate mice that were sacrificed while still healthy. (C) Northern blot analysis for ANF on total RNA prepared from ventricular tissue of littermate animals at 14 or 24 months of age. (D) Electron micrographs of muscular ultrastructure from 3.5 month old (cardiac) and 15.5 month old (skeletal) E2f3−/− animals and 19 month old (cardiac) and 15.5 month old (skeletal) controls.