Table I.

Genotype and allele frequencies of the the studied variants

			Genotype Frequenciesa			Allele Frequenci
Allelic Variantc	Effectd	Ne	Wtf	Het	Var	p
Docetaxel alone (N = 23)g
ABCB1 1236C>T	G411G	23	13 (56.5)	8 (34.8)	2 (8.7)	0.739	0.
ABCB1 2677G>T	A893S	23	11 (47.8)	9 (39.1)	2 (8.7)	0.674	0.
ABCB1 2677G>A	A893Th	23	11 (47.8)	1 (4.3)	0 (0)	0.674	0.
ABCB1 3435C>T	I1145I	23	7 (30.4)	10 (43.5)	6 (26.1)	0.522	0.
Docetaxel Plus Thalidomide (N = 50)
ABCB1 1236C>T	G411G	46	12 (26.1)	18 (39.1)	16 (34.8)	0.457	0.
ABCB1 2677G>T	A893S	50	15 (30.0)	20 (40.0)	15 (30.0)	0.500	0.
ABCB1 3435C>T	I1145I	45	10 (22.2)	23 (51.1)	12 (26.6)	0.478	0.

^aNumber represent number of patients with percentage in parenthesis; the difference in the total number of patients is due Hardy-Weinberg notation for allele frequencies (p, frequency for wild type allele and q, frequency for variant allele);

^cNum represents position in nucleotide sequence;

^dNumber represents amino acid codon;

^egenotype data were not available in all patients as not all samples yielded sufficient DNA or PCR amplified;

^fWT, Homozygous wild-type allele patient; Het, Heterozygous patient; Var, Homozygous variant patient;

^gA single Hispanic male was also included, and his genotype was 1236C>T, unknown; 2677G>T/A, wild-type; 3435C>T, wild-type;

^hThe 2677G>T/A polymorphism is triallelic and two d SNPs are therefore presented.