Table II.
Diplotype Groupings in the initial exploratory analysis
| - Chromosome 1 - | - Chromosome 2 - | Docetaxel Population Frequency (%) |
Docetaxel and Thalidomide Population Frequency (%) |
|||||
|---|---|---|---|---|---|---|---|---|
| Diplotype | 1236C>T | 2677G>T/A | 3435C>T | 1236C>T | 2677G>T/A | 3435C>T | ||
| Diplotype 1 | C | G | C | C | G | C | 7 (33.3) | 4 (9.5) |
| Diplotype 2 | C | G | C | * | * | * | 5 (23.8) | 10 (23.8) |
| Diplotype 3 | C | G | C | T | T | T | 4 (19.0) | 11 (26.2) |
| Diplotype 4 | T | T | T | * | * | * | 3 (14.3) | 9 (21.4) |
| Diplotype 5 | T | T | T | T | T | T | 2 (9.5) | 8 (19.0) |
| Diplotype 6 | - | G | C | - | G | C | 7 (33.3) | 6 (13.6) |
| Diplotype 7 | - | G | C | - | ♦ | ♦ | 3 (14.3) | 8 (18.2) |
| Diplotype 8 | - | G | C | - | T | T | 6 (28.6) | 14 (31.8) |
| Diplotype 9 | - | T | T | - | ♦ | ♦ | 3 (14.3) | 6 (13.6) |
| Diplotype 10 | - | T | T | - | T | T | 2 (9.5) | 10 (22.7) |
*
Any combination of alleles that is not mutually exclusive with another diplotype consisting of all three SNPs.
♦
Any combination of alleles that is not mutually exclusive with another diplotype consisting of only the 2677 and 3435 SNPs.
-
This SNP was excluded in the Diplotypes 6–10 calculations.
Diplotypes were grouped based on whether or not the patient carried a fully wild-type or fully variant haplotype. This approach was based on a report by Kimchi-Sarfaty et al. where it was noted that protein affinity and folding was different between these haplotypes (15).