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. Author manuscript; available in PMC: 2010 Jun 17.
Published in final edited form as: J Am Chem Soc. 2009 Jun 17;131(23):7970–7972. doi: 10.1021/ja902210f

Figure 4.

Figure 4

(a) Peptides 8 and 9. (b) Overlay of the 10 best structures for 9 in aqueous buffer obtained via NOE-restrained dynamics (see text for details). RMSD for the backbone atoms in the strand segments is 0.320 + 0.117 Å. (c) ΔδCαH = δCαH(observed) − δCαH(random coil), or CSD, for α-amino acid residues of macrocycle 9 dissolved in aqueous buffer or in a 1:1 vol:vol solution of aqueous buffer and 2,2,2-trifluoroethanol (TFE).