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. Author manuscript; available in PMC: 2009 Aug 10.
Published in final edited form as: J Mol Biol. 2008 Jan 30;377(4):1144–1160. doi: 10.1016/j.jmb.2008.01.052

Fig. 1.

Fig. 1

Schematic representations of the MMTV promoter and the two human PR isoforms. (a) Functional binding sites located within the MMTV promoter. PREs are indicated by shaded rectangles and labeled 1–4. Site 1 corresponds to the palindromic PRE (GTTACAAACTGTTCT); sites 2–4 correspond to the three half-site PREs of identical sequence (TGTTCT). Binding sites for cofactors are indicated by open rectangles and labeled as NF-1, OCT-1, and TATA. The numbers above the schematic indicate base-pair position relative to the transcriptional start site. Orientation of each PRE is indicated by an arrow below the site. The location of the transcriptional start site is as indicated by the arrow above the schematic. (b) PR-A and PR-B domain structure. Functional regions are as indicated: DBD, DNA binding domain; HBD, hormone binding domain; H, hinge; AF, activation function; BUS, B-unique sequence. PR-B is defined as amino acids 1–933, and PR-A is defined as amino acids 165–933.