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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Hum Genet. 2008 Oct 30;124(5):515–524. doi: 10.1007/s00439-008-0578-5

Figure I. Functional association between IL-10 promoter haplotypes and circulating IL-10 levels.

Figure I

Circulating IL-10 levels for children aged less than 3 years with malaria were measured using the Human Cytokine Twenty-Five-Plex Antibody Bead Kit and results are presented for haplotypic combinations of the IL-10 -1082, -819, and -592 promoter variants. Data are presented as box-plots where the box represents the interquartile range, the line through the box is the median, and whiskers show the 10th and 90th percentiles. Shaded boxes represent individuals with respective haplotypic combinations, while open boxes represent those without the haplotype. The nomenclature for each haplotypic combination is (for example) IL-10 -1082G, -819C and -592C is equivalent to GCC. Data are shown as presence or absence of GCC, ACC, ATC, and ATA haplotypes. Differences in circulating IL-10 levels were considered significant at P<0.05 (Mann-Whitney U tests).