Table 2.
Distribution of IL-10 promoter genotypes in children with malaria
| Genotype | Non-SMA | SMA | Total | P | |
|---|---|---|---|---|---|
| No. of participants | 238 | 137 | 375 | ||
| IL-10-1082A/G | AA, n (%) | 85 (35.7) | 60 (43.8) | 145 (38.7) | |
| AG, n (%) | 120 (50.4) | 55 (40.1) | 175 (46.7) | 0.156a | |
| GG, n (%) | 33 (13.9) | 22 (16.1) | 55 (14.7) | ||
| P(A)=0.61 | P(A)=0.64 | P(A)=0.62 | |||
| IL-10-819T/C | TT, n (%) | 44 (18.5) | 32 (23.4) | 76 (20.3) | |
| TC, n (%) | 109 (45.8) | 58 (42.3) | 167 (44.5) | 0.522a | |
| CC, n (%) | 85 (35.7) | 47 (34.3) | 132 (35.2) | ||
| P(T)=0.41 | P(T)=0.44 | P(T)=0.42 | |||
| IL-10-592A/C | AA, n (%) | 43 (18.1) | 33 (24.1) | 76 (20.3) | |
| AC, n (%) | 100 (42.0) | 49 (35.8) | 149 (39.7) | 0.300a | |
| CC, n (%) | 95 (39.9) | 55 (40.1) | 150 (40.0) | ||
| P(A)=0.39 | P(A)=0.42 | P(A)=0.40 |
Data are presented as proportions (n, %).
Abbreviations: SMA, severe malarial anemia (Hb<6.0 g/dL, with any density parasitemia) (McElroy et al. 1999); Non-SMA, non-severe malarial anemia (Hb≥6.0 g/dL, with any density parasitemia); IL-10, Interleukin-10; P(X), frequency of wild allele in the population.
a
Statistical significance determined by Chi-square analysis.