. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Hum Genet. 2008 Oct 30;124(5):515–524. doi: 10.1007/s00439-008-0578-5

Table 3.

Relationship between individual IL-10 promoter loci and SMA

Genotype	SMA (Hb<6.0 g/dL)

	OR	95% CI	P
IL-10-1082A/G

AA	1.00
AG	0.56	0.27-1.02	0.066
GG	0.94	0.54-1.78	0.902

IL-10-819T/C

TT	1.00
TC	0.88	0.72 - 1.28	0.399
CC	1.24	0.67 - 2.26	0.484

IL-10-592A/C

AA	1.00
AC	0.86	0.51 - 1.42	0.205
CC	1.27	0.71 - 2.28	0.417

Parasitemic children (n=375) were categorized according to a modified definition of SMA based on age- and geographically-matched Hb concentrations (i.e., Hb<6.0 g/dL, with any density parasitemia) (McElroy et al. 1999). Odd Ratios (OR) and 95% confidence interval (CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1 status, bacteremia, and sickle-cell trait (HbAS).