. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Hum Genet. 2008 Oct 30;124(5):515–524. doi: 10.1007/s00439-008-0578-5

Table 5.

Relationship between IL-10 promoter haplotypes and SMA

Haplotype (-1082/-819/-592)		SMA (Hb<6.0 g/dL)

	OR	95% CI	P
GCC	0.68	0.43 - 1.05	0.044
ACC	1.15	0.72 - 1.82	0.544
ATC	1.40	0.52 - 3.78	0.498
ATA	1.92	0.62 - 2.52	0.921

Parasitemic children (n=375) were categorized according to a modified definition of SMA based on age- and geographically-matched Hb concentrations (i.e., Hb<6.0 g/dL, with any density parasitemia) (McElroy et al. 1999). Odd Ratios (OR) and 95% confidence interval (CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1 status, bacteremia, and sickle-cell trait (HbAS).