Table 6.

Multivariate model^* of variables associated with improved survival in the tyrosine kinase inhibitor cohort

Variable	HR (95% CI)	p value
Prior nephrectomy, yes v. no	0.38 (0.19–0.74)	0.005
Time from diagnosis to Rx, mo < 12 v. ≥ 12	0.62 (0.33–1.09)	0.15
Corr Ca++, normal v. high	0.43 (0.23–0.81)	0.008
Hemoglobin, normal v. low	0.57 (0.33–0.98)	0.004
LDH, ≤ 1.5 v. > 1.5 ULN	0.34 (0.15–0.77)	< 0.001
Karnofsy PS, ≥ 80% v. < 80%	0.46 (0.26–0.83)	< 0.001

CI = confidence interval; Corr Ca++ = corrected serum ionized calcium; HR = hazard ratio; LDH = lactate dehydrogenase; PS = performance status; ULN = upper limit of normal.

^*Groups standard model building strategy used for analysis.