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. 2009 Aug 19;4(8):e6667. doi: 10.1371/journal.pone.0006667

Figure 2. Dimorphic sequence motif in the DBL 2X domain of VAR2CSA.

Figure 2

The multiple sequence alignment covers a region of 60–62 amino acids and includes 37 VAR2CSA DBL2X sequences from Senegalese (SG) placental isolates (accession numbers GQ358101 – GQ358135) and 18 database-derived sequences, including P.reichenowi (Reich). This region includes amino acids 580–641 of the VAR2CSA sequence encoded by the 3D7 PFL0030c gene. Color blocks mark positions of the alignment with >55% amino acid sequence identity. The dimorphic sequence motif (DSM) is shown between positions 50–78. All sequences contain one or the other DSM variant. A solid line separates FCR3/It4-type sequences from 3D7 type sequences.