Table 1.
GPCR Databases and Servers.
| Name* | Description | URL | Date of Last Update/Release |
|---|---|---|---|
| PRED-GPCR | A bioinformatics classifier of GPCRs at the University of Athens that uses signature profile hidden markov models to screen sequences against well characterized GPCR families. | http://bioinformatics.biol.uoa.gr/PRED-GPCR/ | 2003 |
| GPCRPR | Classification server that analyzes a query sequence against ∼120 fingerprints. | http://www.biochem.ucl.ac.uk/bsm/dbbrowser/GPCR/ | |
| gpcrPRINTS | A bioinformatics resource at the University of Manchester that profiles a query sequence against the PRINTS fingerprint database to determine most similar families of receptor subtypes. | http://umber.sbs.man.ac.uk/dbbrowser/gpcrPRINTS/ | Nov 2001 |
| IUPHAR-RD | It includes information on GPCR name synonyms, structure, functional assays, agonists and antagonists, transduction mechanisms, distribution, tissue function, and phenotype. | http://www.iuphar-db.org/iuphar-rd/index.html | |
| PDSP | It provides published and unpublished Ki, or affinity, values for a large number of drugs and drug candidates at GPCRs, ion channels, transporters and enzymes. | http://pdsp.med.unc.edu/indexR.html | |
| GLIDA | It integrates information on both GPCRs and their known ligands. | http://pharminfo.pharm.kyoto-u.ac.jp/services/glida/ | Oct 2007 |
| GPCRDB | Information system for GPCRs at the CMBI, in The Netherlands. It contains information about sequences, alignments, 3D models, mutations, and ligand binding constants. | http://www.gpcr.org/7tm | Jun 2006 |
| gpcrTASSER | It contains structual models of all 907 GPCRs of the human genome. | http://cssb.biology.gatech.edu/skolnick/files/gpcr/gpcr.html | Feb 2006 |
| MPKS | It contains atomic coordinates for membrane proteins of known structures. | http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html | Nov 2007 |
| GPCRsclass | A specialized server for the prediction of the classification of the amine type GPCRs, based on dipeptide composition and support vector machines. | http://www.imtech.res.in/raghava/gpcrsclass/ | 2005 |
| hGPCRdb | The human GPCR database at the University Louis Pasteur of Strasbourg. It allows to search for chemogenomics analyses and binding cavity domains. | http://bioinfo-pharma.u-strasbg.fr/gpcrdb/gpcrdb_form.html | 2005 |
| dbCFC | Specialized Cytokine Family Receptor database. | http://cytokine.medic.kumamoto-u.ac.jp/CFC/CK/Chemokine.html | Apr 2006 |
| eGPCRl | List of endogenous GPCRs expressed in various cell lines. | http://www.biomedcomp.com/GPCR.html | Nov 2007 |
| ORDB | Olfactory Receptor Database at Yale University. It supports sequencing and analysis of these receptors. | http://senselab.med.yale.edu/senselab/ORDB/ | Jan 2007 |
| ORMD | Repository for olfactory receptor microarray data. | http://neurolab.med.yale.edu/ormd | 2007 |
| LHRmdb | Specialized Lutenizing hormone receptor mutation database. | http://www2.eur.nl/fgg/endov/lhr.html | |
| GPCR-NaVa | Repository for sequence variants within the family of human GPCRs. | http://nava.liacs.nl/ | Nov 2007 |
| tinyGRAP | GPCR mutant database. | http://www.cmbi.ru.nl/tinygrap/credits/ | 1999 |
| Arcadia | Repository of mutants of GPCR and transporter proteins, and associated information. | http://icb.med.cornell.edu/services/arcadia/start | |
| gpDB | A relational database of G-proteins and their interactions with GPCRs. It contains information about known coupling selectivity of GPCRs to G-protein α-subunits. | http://bioinformatics.biol.uoa.gr/gpDB/ | Apr 2007 |
| CSI | Cell Signaling information for cellular signaling database of pathways and molecules involved in GPCR-mediated and other signal transduction. | http://www.signaling-gateway.org/ | Nov 2007 |
| RINGdb | An integrated biological database providing information about GPCRs and Regulators of G-protein Signaling (RGS). | http://ringdb.csie.ncu.edu.tw/ringdb/ | May2007 |
| GPCR-OKB | Information system for GPCR oligomers. Currently under construction. | http://www.gpcr-okb.org | |
| GRIFFIN | It predicts GPCR-G-protein coupling selectivity using a support vector machine and a hidden Markov model. | http://griffin.cbrc.jp | 2005 |
| GPCRIPDB | Information system for GPCR interacting proteins. Currently under construction. | http://www.gpcr.org/GPCRIP/ | Jun 2005 |
*
CSI, Cell Signaling Information; dbCFC, Data Base of Cytokine Family Class; eGPCRl, Endogenous GPCR List; GLIDA, GPCR-Ligand Database; GPCR, G-protein Coupled receptor; GPCRDB, GPCR Database; GPCRIPDB, GPCR interacting proteins Database; GPCR-NaVa, GPCR Natural Variants; GPCR-OKB, GPCR Oligomerization Knowledge Base; GPCRPR, GPCR Pattern Recognition; gpcrPRINTS, GPCR Protein fingerprints; GPCRsclass, GPCRs Classification; gpcrTASSER, GPCR Threading ASSEmbly Refinement; gpDB, G-Protein Database; GRIFFIN, G-protein Receptor Interacting Feature Finding Instrument; hGPCRdb, Human GPCR Database; IUPHAR-RD, International Union of basic and clinical PHARmacology Receptor Database; LHRmdb, Lutenizing Hormone Receptor Mutation Database; MPKS, Membrane Proteins of Known Structure; ORDB, Olfactory Receptor Database; ORMD, Olfactory Receptor Microarray Data; PDSP, Psychoactive Drug Screening Program; PRED-GPCR, Prediction of GPCRs; RINGdb, Intgrated Database for RGS and GPCRs.