Table 5.

Cox proportional hazards models in a subset of 129 patients who received C-SLED for at least 48 h

Variable	No. of Patients	HR (95% CI)	P Value
Univariate
Age	129	0.99 (0.99–1.01)	0.91
Gender (female vs. male)	129	0.86 (0.54–1.39)	0.15
Primary cancer (solid vs. hematological)	129	0.82 (0.56–1.22)	0.54
SOFA score	129	1.10 (1.03–1.17)	0.003
BMI	129	0.97 (0.94–1.01)	0.09
TPN (yes vs. no)	129	0.61 (0.31–1.23)	0.17
BUN at 48 h	129	0.99 (0.99–1.02)	0.57
BUN at 48 h (≥8 vs. <8 mg/dl)	129	0.57 (0.34–0.94)	0.03
BUN at 48 h (<9 mg/dl)	28	1.00 (Ref)
BUN at 48 h (≥ 9 & <16 mg/dl)	45	0.55 (0.31, 0.99)	0.045
BUN at 48 (≥16 mg/dl)	46	0.78 (0.46, 1.34)	0.37
Serum creatinine at 48 h	129	0.73 (0.49–1.09)	0.13
Serum albumin at 48 h	129	0.70 (0.17–2.86)	0.62
Serum magnesium at 48 h	126	0.86 (0.40–1.86)	0.78
Serum phosphate at 48 h	126	1.03 (0.83–1.29)	0.78
Serum potassium at 48 h	129	0.85 (0.42–1.74)	0.65
Serum ionized calcium at 48 h	125	1.28 (0.99–1.64)	0.06
Blood pH at 48 h	126	0.004 (0–0.17)	0.004
MAP at 48 h	129	0.97 (0.95–0.99)	0.0005
C-SLED duration	129	0.99 (0.99–1.001)	0.43
Multivariate
SOFA score	129	1.10 (1.03–1.18)	0.003
MAP at 48 h	129	0.98 (0.96–0.997)	0.02
BUN at 48 (≥8 vs. <8 mg/dl)a	129	0.57 (0.33–0.98)	0.04

BMI, body mass index; BUN, blood urea nitrogen; CI, confidence interval; C-SLED, continuous sustained low-efficiency dialysis; HR, hazard ratio; MAP, mean arterial pressure; SOFA, sequential organ failure assessment; TPN, total parenteral nutrition.

^aSee Figure 4.