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Pathway mapping of nephrin-mediated repression of NF-κB. (A) Repression of pNF-κB by NPHN is abrogated by co-transfection with dominant negative IκBα (IκM) and rescued by co-transfection with WT IκB in MDCK cells. (B) Repression of pNF-κB by NPHN is abrogated by co-transfection with dominant negative aPKCζ (PKC-DN) in MDCK cells. (C) Repression of pNF-κB by WT NPHN is abrogated by increasing concentrations of dominant negative 14-3-3 (DN1 = 4 μg/μl; DN2 = 6 μg/μl) in MDCK cells.
