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Electron microscopic analysis of CXCR4 null glomeruli. Low-magnification (top) and high-magnification (middle) images show foot process effacement (arrows) after CXCR4 ablation, although endothelial cells and podocytes are securely attached to the GBM. (Bottom) There are fewer fenestrations in CXCR4 null glomeruli than in normal glomeruli (arrows). Magnifications: ×2000 in top; ×10,000 in middle and bottom.
