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. 2009 Aug;20(8):1714–1723. doi: 10.1681/ASN.2008060640

Figure 8.

Figure 8.

Analysis of the kidneys from endothelial cell–specific CXCR4 KO mice. (A through F) PAS-stained kidney sections of CXCR4 flox/+ (as a control; A) and Tie2-Cre CXCR4 flox/flox mice (B through F) 3 d after birth. (A and B) Low-magnification images. Arrows indicate abnormally dilated tubules. (C and D) Magnified view of B (right). Proximal tubules are dilated and flattened in shape with vacuolations (arrows). (E and F) Glomeruli of Tie2-Cre CXCR4 flox/flox mice exhibit ballooning of the capillary tuft, identical to conventional CXCR4 null glomeruli. Some endothelial cells are detached from the GBM (arrows). (G) Electron microscopic images of glomeruli from Tie2-Cre CXCR4 flox/flox mice. Endothelial cells detached from the GBM are shown magnified (middle and right). Magnifications: ×100 in A and B; ×200 in C; ×1000 in D through F; ×2000 in G, left; ×10,000 in G, middle and right.