Table 2.
Median values of kidney injury biomarkers: HIV-positive patients with HIVAN and other cohortsa
| NGAL (μg/g creatinine) | Serum Creatinine (mg/dl) | GFR (ml/min) | Protein/Creatinine Ratio | |
|---|---|---|---|---|
| Control, HIV-positive, race-matched (n = 24) | 28 (4–481)c | 0.9 (0.4–1.2)c | 116 (83–251)c | 0.0 (0.0–0.0) |
| Control, HIV-positive, non-race-matched (n = 14) | 74 (5–361) | 0.8 (0.4–1.0)c | 114 (83–246)c | 0.0 (0.0–0.3)c |
| CKD, HIV-positive, HIVAN (n = 13) | 231 (18–4050) | 2.6 (0.9–18.5) | 30 (4–117) | 0.6 (0.0–9.6) |
| CKD, HIV-positive, race-matched (n = 6) | 88 (5–374) | 2.1 (1.1–3.4) | 37 (24–190) | 0.2 (0.0–8.2) |
| CKD, HIV-positive, non-race-matched (n = 10) | 51 (19–225) | 1.5 (0.3–2.2) | 57 (13–344) | 0.5 (0.0–9.2) |
| CKD, HIV-negative (n = 106) | 12 (1–344)c | 1.5 (1–12.6) | 43 (5–90) | N/A |
| CKD, HIV-negative, membranous (n = 16) | 8 (1–248)c | 1.3 (0.5–3.2)b | 56 (21–128) | 4.5 (1.0–15.3)b |
| CKD, HIV-negative, FSGS (n = 7) | 19 (4–67)b | 1.2 (1.1–3.7) | 73 (17–63) | 1.9 (1.0–2.4) |
| CKD, HIV-negative, diabetic and hypertensive kidney diseases (n = 12) | 32 (2–316)b | 2.7 (0.7–3.6) | 26 (18–98) | 2.3 (0.2–27.9) |
| AKI, all causes (n = 30) | 296 (11–1833) | 3.9 (0.7–28.6) | 16 (2–53) | N/A |
aAll data presented as median (range). N/A, not available.
bP value <0.05 in comparison with the HIVAN cohort.
cP value <0.01 in comparison with the HIVAN cohort.