Table 3.
Distribution of mutations in lymphoma VH segments
| Case # | CDR 1&2 |
FWR 1,2&3 |
||||||
|---|---|---|---|---|---|---|---|---|
| R* | S | R/S | Random R/S | R | S | R/S | Random R/S | |
| 1 | 8 | 1 | 8.0 | 4.3 | 6 | 4 | 1.5 | 3.0 |
| 2 | 5 | 3 | 1.7 | 4.3 | 5 | 7 | 0.7 | 3.0 |
| 3 | 3 | 1 | 3.0 | 4.5 | 9 | 11 | 0.8 | 2.7 |
| 4 | 4 | 4 | 1.0 | 4.5 | 13 | 11 | 1.2 | 2.7 |
| 5 | 4 | 3 | 1.3 | 4.5 | 6 | 6 | 1.0 | 2.7 |
| 6 | 3 | 0 | 3 | 4.1 | 3 | 3 | 1 | 2.7 |
| 7 | 9 | 3 | 3 | 3.9 | 6 | 3 | 2 | 2.9 |
| 8 | 5 | 3 | 1.7 | 4.2 | 11 | 5 | 2.2 | 2.8 |
| 9 | 4 | 1 | 4 | 3.6 | 3 | 2 | 1.5 | 2.9 |
| 10 | 6 | 5 | 1.2 | 3.5 | 5 | 7 | 0.7 | 3.3 |
*
Columns headed by “R” or “S” give the number of replacement or silent mutations, respectively, relative to the most closely related germline VH gene segment. “Random R/S” refers to the ratio of all possible replacement to silent mutations.