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. Author manuscript; available in PMC: 2009 Dec 25.
Published in final edited form as: Nature. 2009 May 20;459(7250):1126–1130. doi: 10.1038/nature08062

Figure 4. Calcineurin suppression by DSCR1 and DYRK1A attenuates endothelial cell activation.

Figure 4

(a, b) Cyclooxygenase-2 (COX-2) mRNA (a) and protein expression (b) was quantified by qPCR and Western blot analysis in endothelial cells isolated from Dscr1 wild-type (WT) and transgenic (Tg) mice. (c) Western blot analysis of endothelial cells isolated from Dscr transgenic mice and probed for DYRK1A after either mock infection (mock) or retroviral infection with Dyrk1A (DYRK1A). (d) Endothelial cells isolated from Dscr1 transgenic (Tg) mice with DYRK1A over-expression (+DYRK1A) demonstrate an even greater suppression of VEGF-mediated proliferation as compared to wild-type (WT) and DSCR1 over-expression alone (mock). Values are mean ± sem, *p<0.01.