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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: J Immunol. 2009 Jun 15;182(12):7353–7363. doi: 10.4049/jimmunol.0900657

Figure 1.

Figure 1

IL-10 expression negatively influences high-dose primary flu challenge. Age-matched WT or IL-10 KO mice were challenged with 1LD50 A/PR8 (5000 EID50). (A) weight loss and conditional survival (n=15 mice / group, and * = P < 0.05 from 1 of 5 similar experiments (exp)). (B) WT mice infected with 1 LD50 A/PR8 were treated with either IL-10 receptor blocking antibody or an isotype control, as described, and weight loss and conditional survival monitored (n=8, and * = P < 0.05 from 1 of 2 independent exp). Weight loss in A-B is of all surviving animals. (C) On stated days post-infection, viral titers were determined by quantitative PCR (n=5 / group / day from 1 of 3 similar exp), and (D) respiratory rates and minute volumes monitored (n= at least 7, * = P < 0.05, and *** = P < 0.001 from 1 of 2 independent exp). (E) H&E stained lung sections were scored blindly for levels of immunopathology (n=3–7 mice / group / day from 1 of 2 exp).