Table 1.
Comparison of amino acid sequences of human MBP epitopes identified in HLA-DR Tg mice with corresponding murine MBP epitopes.
| Epitop | Sequence |
|---|---|
| Human MBP64-78 | ARTAHYGSLPQKSHG |
| Murine MBP60-75 | TRTTHYGSLPQKSQHG |
| Human MBP 82-100 | DENPVVHFFKNIVTPRTPP |
| Murine MBP 79-97 | DENPVVHFFKNIVTPRTPP |
| Human MBP111-129 | LSRFSWGAEGQRPGFGYGG |
| Murine MBP108-126 | LSRFSWGAEGQKPGFGYGG |
| Human MBP138-151 | HKGFKGVDAQGTLS |
| Murine MBP135-149 | HKGFKGAVDAQGTLS |
The core epitope of human MBP epitopes underlined, and the changes (substitution or insertion) in the murine MBP epitopes in bold.