qPCR analysis of SSTR1 and SSTR2A mRNA levels in spinal cultures in response to incubation with HIS, 5-HT, and SOM. Incubation with SOM alone increased SSTR1 levels, whereas HIS and 5-HT induced elevated mRNA levels for both peptide receptors. Coincubation of HIS, 5-HT, and SOM lowered mRNA levels compared with HIS- and 5-HT-incubated dishes. *Statistically significant difference compared with nonstimulated control dishes (P < 0.05) and statistically significant difference HIS+5-HT+SOM-stimulated dishes compared with HIS+5-HT-stimulated dishes (P < 0.05).