Fig. 3.

Receiver-operating characteristic (ROC) curves of pulse detection accuracy obtained by deconvolution analysis in 9 young men given a GnRH receptor antagonist and then infused with 8 randomly varying pulses of recombinant human LH and 2 of saline (see Fig. 1). Three paired-threshold criteria were used as defined by minimal incremental and %changes of 0.3 IU/l and 9.0% (left), 0.2 IU/l and 6.5% (middle), and 0.1 IU/l and 4.0% (right). Different thresholds yielded slightly different specificities and sensitivities, whereas Akaike (AIC) and Bayesian information criteria (BIC) yielded identical sensitivity and specificity in each subject. Hence, each part shows 9 points (○), although some points are coincident. Overall, sensitivity and specificity (▾) were calculated for each panel by pooling all data (methods).