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. 2009 Jun 16;297(2):E552–E559. doi: 10.1152/ajpendo.00220.2009

Fig. 1.

Fig. 1.

Changes in glucose disposal rate (GDR) during the hyperinsulinemic hyperlipemic euglycemic clamp following a 12-wk exercise/diet intervention. Older obese men and women (n = 16) underwent 12 wk of exercise training (1 h/day, 5 days/wk at 65% maximal oxygen uptake). Participants either maintained their habitual dietary intake [eucaloric group (EX): 1,684 ± 196 kcal/day; A] or were counseled to reduce caloric intake [hypocaloric group (EX-HYPO): 1,293 ± 63 kcal/day; B]. Error bars represent SE. Open bars indicate preintervention means; filled bars represent postintervention means. The x-axis indicates the insulin-stimulated (INS) and intralipid/heparin (INS + FFA) stages of the clamp. Postintervention GDR was significantly elevated above baseline during both INS and INS + FFA stages in both groups (apre- vs. postintervention, P < 0.05). Prior to the intervention, lipid infusion reduced GDR compared with insulin stimulation alone in both groups (eINS + FFA vs. INS, P < 0.05). Lipid-induced insulin resistance was no longer evident following the study (INS + FFA vs. INS, P = 0.17). FFM, fat-free mass.