Fig. 5.

Exogenous SHH on wound healing in STZ-induced diabetic mice. After STZ treatment (10 wk), a full-thickness excisional wound (1.5 × 1.5 cm) was made. The solution of SHH (20 μg/ml) or the selective SHH receptor inhibitor cyclopamine (5 nmol/l) was directly placed on the wound surface for 30 min every other day from day 1 after wounding. The rate of wound closure was monitored every other day by tracing the wound area. Values were presented as means ± SE; n = 5. P < 0.05 vs. control (*) and vs. STZ (#).