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(A) modified segmentation of simulated case 06: (top) the 4 prior images; (bottom) the segmented tissues (GM, WM, CSF) and a first approximation of the extra class. (B) modified segmentation of the same case using the result of the first segmentation run as priors on the extra class. Note that the damage (i.e. spatially located in WM but with T1 signal close to GM) is now classified in the lesion class and not as intact WM.
