Fig. 4.

(A) Signal-to-probability maps of simulated case 06. These maps represent a scatter-plot between the T1 image and the segmented tissues. T1 values are coded in an arbitrary unit (from 100 to 700). The GM probability is shown in dark gray and the WM probability is shown in light gray. For display purposes, the WM probability values are multiplied by − 1. Voxels located in the WM but correctly classified as lesion (in the extra class) are shown in black. (B) After removing the voxels inside the lesion (those shown in black in A), the signal-to-probability maps of simulated case 06 are comparable to those of a normal brain (both GM and WM tissues are no longer contaminated by the lesion).