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. Author manuscript; available in PMC: 2010 Jul 17.

Published in final edited form as: J Mol Biol. 2009 May 23;390(3):368–379. doi: 10.1016/j.jmb.2009.05.037

The crystal structure of the ternary complex of tPolλ (blue), gapped DNA substrate (black), and ddTTP (multi-colored) ²³. (A) overall structure; (B) a close-up view detailing the interaction between R386 (red) and ddTTP; (C) a close-up view detailing the interaction between R275 (red) and the 5’-phosphate of the downstream primer terminus.

The crystal structure of the ternary complex of tPolλ (blue), gapped DNA substrate (black), and ddTTP (multi-colored) ²³. (A) overall structure; (B) a close-up view detailing the interaction between R386 (red) and ddTTP; (C) a close-up view detailing the interaction between R275 (red) and the 5’-phosphate of the downstream primer terminus.