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. 2009 Aug 3;5:553–559. doi: 10.2147/tcrm.s6178

Table 3.

Common adverse events reported during long-term treatment with rhIGF1 in primary IGF-1 deficiency

Adverse events %
Hypoglycemia 49
Hypoglycemic seizure 5
Hypoacusisa 22
Snoring 22
Tonsillar/adenoid hypertrophy 22
Tympanostomy tube placement 16
Sleep apnea 4
Tonsillectomy/adenoidectomy 11
Thymic hypertrophy 35
Lipohypertrophy 32
Orthopedic events 20
Intracranial hypertension 4
Nephrolithiasis 3

Abbreviations: IGF-1, insulin-like growth factor-1; rhIGF1, recombinant IGF-1.