Echocardiographic changes before and after BNP therapy. In A, ejection fraction in the BNP cohort was preserved compared with the control cohort throughout the experiment. Similarly, in B, LV end-diastolic dimension (LVEDD) was smaller in BNP-treated dogs after Embo+Inf and Obs. LV mass, as shown in C, showed no change after BNP therapy during Embo+Inf and Obs, in contrast to control therapy, which demonstrated a significant increase in LV mass after embolization and after a period of observation. *P < 0.05 vs. baseline, †P < 0.05 vs. Embo+Inf, ‡P < 0.05 vs. control, ¶P < 0.005 vs. control.