Fig. 3.

Changes in arterial blood pressure and heart rate produced by H₂O₂ alone or combined with kynurenate injected into the intermediate NTS. ABP and HR traces of an anesthetized rat (A) and a conscious rat (B) that received H₂O₂ into the intermediate NTS before and after injection of kynurenate (KYN) into the same area. Changes in MAP (C) and changes in heart rate (HR) (D) to H₂O₂ into the intermediate NTS before, 10, and 60 min after kynurenate injection into the same area in anesthetized rats (n = 7). Changes in mean arterial pressure (E) and changes in heart rate (F) to H₂O₂ into the intermediate NTS before, 5 to 10 and 60 min after kynurenate injection into the same area in conscious rats (n = 5). Doses of H₂O₂ were 50 nmol and 500 pmol, respectively, in conscious and anesthetized rats. The dose of kynurenate was 7 nmol in both groups. Dashed vertical lines in A and B show the moment of injection into the NTS. Results in C–F are expressed as means ± SE. *Significantly different from before KYN (P < 0.05, ANOVA followed by Student-Newman-Keuls test).