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Nesfatin-1 reduces food intake. Centrally administered nesfatin-1 led to a dose-related, significant decrease in food intake (A) and water drinking (B) when injected at 1650 into ad libitum-fed and watered rats. Data were analyzed with ANOVA and Scheffé's multiple comparison. *P < 0.05, **P < 0.01, and ***P < 0.001, vs. saline vehicle-injected controls.
