Fig. 2.
Effects of COX-1 and COX-2 inhibitors on the thermal responses to LPS at a subneutral Ta. Rats kept at a Ta of 22°C were pretreated with a COX-1 inhibitor (SC-560, 5 mg/kg iv), a COX-2 inhibitor (SC-236, 2.5 mg/kg iv), or their vehicle before the intravenous administration of LPS (doses indicated) or saline. Compared with the vehicle pretreatment, SC-560 blocked the hypothermic response to LPS (P < 2.2 × 10−5, 50–420 min for either LPS dose), whereas SC-236 enhanced the hypothermic response (P < 2.2 × 10−5, 80–420 min for the lower LPS dose, 130–420 min for the higher LPS dose).