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. 2009 Jun 3;297(2):F333–F340. doi: 10.1152/ajprenal.00207.2009

Fig. 1.

Fig. 1.

S-nitroso-N-acetyl-dl-penicillamine (SNAP) and 8-bromo-cGMP reduce the amplitude and frequency of carbachol-enhanced spontaneous contractions (SCcarb). A: carbachol-induced enhancement of spontaneous activity in a bladder strip from neonatal rat. Arrow indicates time of carbachol (100 nM) application. B: concentration dependence of SNAP-mediated inhibition of SCcarb amplitude (n = ≥7 for each concentration). C and E: inhibition of SCcarb by 100 μM SNAP (C) and 100 μM 8-bromo-cGMP (E). D and F: summary data showing average effect of 100 μM SNAP (n = 15) and 100 μM 8-bromo-cGMP (n = 13) on SCcarb amplitude (D) and frequency (F). G: summary of inhibition of SCcarb amplitude by 2 consecutive applications of 100 μM SNAP followed by 1 application of 100 μM 8-bromo-cGMP (n = 12). *P < 0.05 compared with control. #P < 0.05 between groups. **P < 0.05 compared with maximum SNAP inhibition by 2-tailed t-test with layered Bonferroni correction.