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. 2009 Jun 3;297(2):F333–F340. doi: 10.1152/ajprenal.00207.2009

Fig. 4.

Fig. 4.

Role of PKG in SNAP- and 8-bromo-cGMP-mediated inhibition of SCcarb. A: 100 μM 8-bromo-cGMP was added to a bladder strip without (top) or with (bottom) PKG inhibitor (25 μM Rp-cGMPS). B: PKG inhibition reversed the inhibitory effect of 100 μM 8-bromo-cGMP. C: 100 μM SNAP added to a bladder strip pretreated with 25 μM Rp-cGMPS. D: summary data showing 100 μM 8-bromo-cGMP inhibition of SCcarb contraction in the presence and absence of 25 μM Rp-cGMPS (n = 9). E: summary data showing 25 μM Rp-cGMPS reversal of 100 μM 8-bromo-cGMP inhibition of SCcarb contraction (n = 4). E and F: summary data showing 100 μM SNAP inhibition of SCcarb amplitude in the presence and absence of 25 μM Rp-cGMPS (n = 10). *P < 0.05, **P < 0.01 between groups by 2-tailed t-test with layered Bonferroni correction.