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Po2 in the concentric regions as a function of interregion O2 permeability (P
) for 10 (A), 100 (B), and 1,000 (C) times baseline value. When regionalization is reduced by increasing boundary O2 permeabilities, differences between interstitial Po2 become smaller, although the effect is noticeable only for a ≥100-fold increase, owing to the predominance of capillary flows in the interregion O2 exchange at sufficiently low boundary O2 permeabilities.
