Table 1.
Baseline data in different FGFR−/− mice
| Control-1 | FGFR1−/− | Control | FGFR3−/− | FGFR4−/− | |
|---|---|---|---|---|---|
| Serum phosphorus, mg/dl | 6.6±0.4 (n=16) | 6.2±0.4 (n=15) | 7.6±0.4 (n=12) | 7.0±0.4 (n=12) | 7.9±0.4 (n=12) |
| Serum FGF23, pg/ml | 116.9±7.5 (n=23) | 173.9±17.3† (n=21) | 151.3±9.6 (n=15) | 140.4±11.4 (n=16) | 190.7±10.4*‡ (n=14) |
| Serum 1,25(OH)2D3, pmol/l | 81.1±11.0 (n=16) | 85.8±13.0 (n=15) | 88.9±15.9 (n=10) | 208.7±27.3*(n=11) | 154.2±35.0 (n=10) |
| Serum PTH, pg/ml | 148.4±16.1 (n=14) | 115.2±17.6 (n=17) | 130.4±26.6 (n=29) | 213.6±41.3 (n=31) | 100.9±16.3 (n=21) |
Values are means ± SE; n=no. of mice. FGFR, FGF receptor; PTH, parathyroid hormone.
*
P < 0.05 vs. control.
†
P < 0.05 vs. control-1.
‡
P < 0.05 vs. FGFR3−/−.