Table 3.
Serum parameters in control, FGFR3−/−, and FGFR4−/− mice post-FGF23 administration
| Control |
FGFR3−/− | FGFR4−/− | ||||
|---|---|---|---|---|---|---|
| Vehicle | FGF23 | Vehicle | FGF23 | Vehicle | FGF23 | |
| Serum phosphorus, mg/dl (pre- vs. post-FGF23 | 7.7±0.3 vs. 8.1±0.5 (n=12) | 8.5±0.4 vs. 6.5±0.5a (n=12) | 8.4±0.6 vs. 8.9±0.4 (n=12) | 8.0±0.4 vs. 5.4±0.3a (n=12) | 8.4±0.6 vs. 9.0±0.5 (n=12) | 8.7±0.3 vs. 7.6±0.4a (n=12) |
| Serum FGF23, pg/ml | 239±29.5 (n=6) | 1011.5±216.7d (n=6) | 201.2±53.7 (n=6) | 1,658.1±223.3c (n=6) | 279±32.6 (n=6) | 1,548.4±135.2c (n=6) |
| Serum 1,25(OH)2D3, pmol/) | 78.4±32.4 (n=6) | 7.4±0.6b (n=6) | 171.4±28.7 (n=10) | 14.9±5.7d (n=6) | 121.0±17.3 (n=6) | 33.8±6.2d (n=6) |
| Serum PTH, pg/ml | 88.2±18.9 (n=6) | 75.1±20.0 (n=6) | 244.4±31.9e (n=6) | 253.0±55.6 (n=6) | 117.2±25.2f (n=13) | 162.4±39.4 (n=10) |
Values are means ± SE.
a
P ≤ 0.001, pre- vs. post-FGF23.
b
P ≤ 0.05, vehicle vs. FGF23.
c
P < 0.001, vehicle vs. FGF23.
d
P ≤ 0.005, vehicle vs. FGF23.
e
P < 0.05, control vehicle vs. FGFR3−/− vehicle.
f
P < 0.05 FGFR3−/− vehicle vs. FGFR4−/− vehicle.