Fig 4.

Interleukin (IL)-17 induces the expression of immune chemoattractants that are upregulated in psoriatic skin. (a) Quantitative reverse transcriptase–polymerase chain reaction (RT-PCR) analysis of chemokine gene expression in primary keratinocytes treated with IL-17, IL-22 or interferon (IFN)-γ expressed as fold change difference from control. Error bars indicate SD of biological triplicates. (b) RT-PCR quantification of chemokine gene expression normalized to HARP in paired samples of nonlesional (NL) and lesional skin (LS) from patients with psoriasis (n = 16). Open circles represent individual patients. Red lines represent the mean. Asterisks indicate statistical significance: *P < 0.05, **P < 0.01, ***P < 0.005.