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SD2 region mutant (DNH). (A) The activity without CoCl2 but in the presence of 4 mM MgCl2 of Tdt wild-type, D473A, N474A and H475A, along with the double mutant switching DNH into NSH (as in pol μ) or into ANA, is shown for each dNTP and a mixture of all dNTPs. (B) The effect of Co++ addition (1 mM) to the reaction buffer is shown in the lower panel.
