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(A) Representative examples of anaphase chromatin bridging and teardrop structures suggestive of aberrant cytokineses in αKD and αβKD cells depleted of topo 2 (3 days dox). DNA has been stained with DAPI. Scale bar, 10 μm. (B) Summary graph of the frequency of anaphase bridging after 3 days dox. Data points are based on three experiments, with a total of >150 anaphases examined. (C) Detection of occasional ‘teardrop’ structures in topo 2-depleted (3 days dox) DT40 cells.
