. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: J Clin Pharmacol. 2008 Jul 17;48(9):1081–1091. doi: 10.1177/0091270008321789

Table I.

Mean (SD) Parameter Values From the Models Used to Optimize Antiretroviral Therapy in This Report

Drug	Type	k_a	V_d	CL
Nelfinavir³⁴	Pediatric	0.4 (0.2) h⁻¹	6.4 (2.5) L/kg	1.0 (0.2) L/h · kg
Efavirenz³⁵,³⁶	Pediatric	0.3 (0.1) h⁻¹	4.2 (1.1) L/kg	0.1 (0.03) L/h · kg
fos-Amprenavir³⁷,³⁸	Adult	3.0 (1.3) h⁻¹	5.7 (1.5) L/kg	0.7 (0.2) L/h · kg
Atazanavir³⁹	Adult	1.0 (0.3) h⁻¹	86.2 (14.9) L	8.1 (0.9) L/h

Models based on pediatric studies were used for patients with a Tanner Sexual Maturity Rating stage ≤3. References indicate the source articles for initial parameter estimates.