FIG. 5.
Blockade of HCN channels increases the somatic impact of dendritic excitatory input. A: somatic voltage traces (Vsoma) evoked by barrages of simulated EPSCs injected at a distal apical dendritic site (Idend) under control and in the presence of ZD 7288 (20 μM). Traces are gray-scaled for clarity. The morphology of the neuron is shown in the inset (scale bar = 100 μm). B: summary data (P26-29; n = 6; means ± SE) describing the somatic depolarization generated by dendritic simulated synaptic current under control (○) and in the presence of ZD 7288 (•). Values of injected current and evoked voltage responses represent the average amplitude throughout the barrage. Data were fit by linear regression (—).