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. 2009 Jun 3;102(2):1160–1171. doi: 10.1152/jn.00266.2009

FIG. 1.

FIG. 1.

Cannabinoid CB1 receptor-dependent long-term depression (LTD). A: averaged time course of excitatory postsynaptic currents (EPSCs) (normalized). LTD was induced in autaptic neurons using a 6-min 4-Hz (1-s on-off) stimulus (see methods). Dashed vertical lines indicate the period of low-frequency stimulation. Inset: sample traces at time points indicated before (1) and after (2) induction of LTD. Scale bars: 1 nA, 10 ms. B: averaged time course of EPSCs (normalized) in response to the LTD stimulus in neurons cultured from mice lacking the CB1 receptor (CB1−/−). C: sample time course showing LTD reversal by the CB1 antagonist SR141716 (100 nM). D: bar graph summarizing data from A and B showing a comparison of relative EPSC charge under control conditions, in CB1 −/− cultures following the 4-Hz stimulus (*P < 0.001 CB1−/− vs. CB1+/+ control, 1-way ANOVA with Dunnett's post hoc test). E: bar graph summarizing reversal of established autLTD by 100 nM SR141716 (*P < 0.05, paired t-test).