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Phytocannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) antagonizes autaptic LTD. A: Δ9-THC (1 μM) application during the LTD-inducing stimulus (•) prevents LTD (n = 5). B: bar graph summarizing the average normalized EPSC following the LTD-inducing stimulus in Δ9-THC-treated neurons—control LTD is shown for reference (*, P < 0.05 1-way ANOVA, Dunnett's post hoc test vs. control LTD).
