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. 2009 Jun 3;102(2):1160–1171. doi: 10.1152/jn.00266.2009

FIG. 6.

FIG. 6.

Phospholipase C (PLC) inhibition reverses autLTD presynaptically. A: 2-AG-induced autLTD is reversed by treatment with the PLC blocker U73122 (2 μM). B: similarly, 2-AG-induced autLTD is partially reversed by treatment with the PLC inhibitor edelfosine (10 μM). C: bar graph summarizes same-cell data for cells with 2-AG-induced autLTD (Ctrl) and either subsequent treatment with U73122 (n = 6) or edelfosine (n = 5). D: sample spontaneous miniature PSCs from a neuron with 2-AG-induced LTD (autLTD) and after treatment with U73122 (autLTD/U73122). Scale bars: 15 pA, 100 ms. E and F: U73122 increases frequency but not amplitude of mEPSCs. Bar graph summarizes same-cell miniature EPSC (mEPSC) amplitudes and frequencies for conditions described in D (n = 4). G: sample spontaneous miniature PSCs from neuron with 2-AG-induced LTD (autLTD) and after treatment with edelfosine (autLTD/edelfosine). Scale bars: 15 pA, 100 ms. H and I: edelfosine increases frequency but not amplitude of mEPSCs. Bar graph summarizes same-cell miniature EPSC amplitudes and frequencies for conditions described in G (n = 5). *, P < 0.05 by paired t-test.